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When this flexibility is lost, as is often seen in chronic post-viral syndromes, the body becomes locked in a state of perpetual energy debt and systemic inflammation

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Chronic stress and inflammatory stimuli promote microglial activation, leading to sustained release of pro-inflammatory cytokines, reactive oxygen and nitrogen species, and excitotoxic mediators that disrupt synaptic function and neuronal integrity ( Neuroinflammation also interacts bidirectionally with dysregulation of the hypothalamicpituitaryadrenal (HPA) axis