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Cuccurazzu B, et al
Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant
In rats, prenatal ethanol exposure leads to hypermethylation of the promoter for the astrocyte GFAP gene and to reduction in GFAP expression during early postnatal development (Valls et al., 1997)
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