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Novo Nordisk made three critical modifications: C-18 fatty diacid side chain: Instead of liraglutide's C-16 palmitoyl chain, semaglutide uses a longer C-18 fatty diacid connected through a mini-PEG linker
The end result is lower blood sugar, less food intake, and more feelings of fullness and satiety
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The human translation is unclear
Eligibility generally follows standard clinical thresholds: adults with BMI 30 kg/m, or BMI 27 kg/m with at least one weightrelated comorbidity, are typical candidates after screening
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