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GLP-1 RA exenatide alleviated the polycystic ovarian morphology in rats with PCOS, semaglutide treatment not only alleviated PCOS phenotypes but also reversed ovarian ferroptosis markers, restored GPX4 expression, and reduced the GPX4 promoter hypermethylation and DNMTs levels, with efficacy comparable to 5-azacytidine
It can also work against weight loss if it leads to a cycle of strict restriction followed by high energy intake, which over time may cancel out the calorie deficit the method aims to create
This dual mechanism explains the unprecedented weight loss numbers from clinical trials
muscle cells
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