is glp 1 insulin GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation Mechanism by which excessive circulating

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Conversely, overfeeding increases intra-portal insulin levels that enhances hepatic GH sensitivity to a degree where relatively low GH secretion is sufficient to maintain ambient hepatic IGF-I synthesis and secretion, and normal circulating IGF-I levels (7)

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