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The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks
The pyroptotic process is typically initiated by recognition of pathogens in the cytosol or endogenous danger signals via inflammasomes, which recruit and activate inflammatory caspases such as caspase-1, -4, -5, -11 (160, 161)
It is known to activate telomerase, which helps maintain telomere length in cells
Ashworth, A
Presented for research literature review only Yang K et al
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