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Fleming R, Estey E, Kantarjian H, OBrien S, Keating M, Kornblau S, Freireich E, Andreeff M , Cortez J, Vassilaki M, Turan A, Risser J, Luna M, Anaissie E
CrossRef Psychological distress in cancer survivors: a population-based analysis and machine learningbased risk stratification Jeong Yun Jang, Dawoon Jeong, Hyeon Kang Koh, Kyunghye Bang, Gyurim Kim, Semie Hong Supportive Care in Cancer.2026;[Epub] CrossRef Latency period of lung cancer in relation to tobacco smoking in Korea Thi Tra Bui, Hee-Yeon Kang, Eunjung Park, Jin-Kyoung Oh Epidemiology and Health.2026
It helps reduce appetite and support calorie control
Acetaminophen in doses above 2g/day (saturates sulfation and glucuronidation, depletes glutathione catastrophically) R Alcohol (depletes glutathione, NAD+, SAM-e, and directly damages hepatocytes) R Charcoal-grilled meats (heterocyclic amines that undergo bioactivation via sulfation and acetylation, generating DNA-reactive intermediates) R Chronic NSAID use (competes for glucuronidation and amino acid conjugation pathways) Excess fructose (depletes ATP and drives uric acid production, impairing energy-dependent conjugation) R Glyphosate residues on non-organic produce (disrupts glycine metabolism and chelates manganese) R High-dose turmeric or quercetin without cycling (both inhibit SULT1A1 and can paradoxically impair sulfation at high sustained doses) R Processed foods with benzoate preservatives (benzoic acid consumes glycine through conjugation, depleting the glycine pool for other Phase II reactions) R Proton pump inhibitors chronically (reduce magnesium absorption, impair glucuronidation) R Testing These tests can help identify which conjugation pathways are impaired and what is contributing to the dysfunction
Blazheva D, et al
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