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We wanted to resolve the lack of consensus with our work. Analyzing de-identified patient data collected from December 2017 through December 2024 across 12 databases managed by the Observational Health Data Sciences and Informatics (OHDSI) network-an international and interdisciplinary collaborative of researchers and observational health databases the researchers followed the health outcomes of adults with type 2 diabetes who had been prescribed semaglutide (227,971), dulaglutide (68,588), exenatide (5,460), empagliflozin (252,356), sitagliptin (100,083) or glipizide (213,515) for the first time
Gonnella, D
10.1001/archinte.163.20.2433 Arch
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In humans, the CYP450 enzyme that predominately catalyses the formation of NAPQI is CYP2E1, although in vitro CYP3A4, CYP2D6 and CYP1A2 have also been implicated in the formation of the toxic metabolite [18,19,20]
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