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We do use proxies for that looking at my stress levels, looking at my sleep quality and a whole bunch of other stuff to basically try to assess whether anything in my life is creating unhealthy conditions

Full text: Dimova, S., Hoet, P

the doses were escalated every 4 weeks starting from 0.25 mg to 0.5 mg, 1.0 mg, and 1.7 mg until a dose of 2.4 mg was met and maintained for the remaining 16 weeks