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Notably, acetylcarnitine can act as an acetyl donor [37], supporting the acetylation process of cells through the shuttle mechanism of acetylcarnitine in the absence of conventional acetyl-CoA synthetase enzymes such as ATP-citrate lyase (ACLY) and acyl-CoA synthetase short chain 2 (ACSS2) [38]
Our group previously demonstrated that Naotai Formula (NTF) enhances the HSF1/HSPB1 pathway and regulates brain iron homeostasis by suppressing TFR1/dMT1 and activating SCL7A11/GPX4, thereby protecting against ferroptosis in MCAO rats (177, 178)
10.1053/j.gastro.2012.02.003 22
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