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Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling
Similarly, GLP1-RA exenatide once weekly for 26 weeks reduced brain response, as measured by functional magnetic resonance imaging (fMRI), to alcohol cues in the ventral tegmental area 19
Role of glutathione in heat-shock-induced cell death of Saccharomyces cerevisiae
Biochim Biophys Acta 1988
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