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Major Renal Na + and K + Transporter The major basolateral membrane transporter involved in renal Na + and K + exchange is the primary renal Na + /K + -ATPase which is composed of the 1 -subunit encoded by the ATP1A1 gene and the 1 -subunit encoded by the ATP1B1 gene
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1 The GIPR association was specific to tirzepatide, Eli Lilly's dual GLP-1 and GIP receptor agonist sold as Mounjaro and Zepbound, with carriers of that variant found to be 83% more likely to experience vomiting than non-carriers
