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This structural modification significantly extends its half-life and enhances resistance to proteolytic degradation, thereby enabling prolonged biological activity in vivo

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Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 [PMID: 24633053] Laboratory literature summary: Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1