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Tirzepatide is administered subcutaneously once weekly at doses ranging from 2.5 mg to 15 mg, with gradual dose escalation recommended to minimize gastrointestinal adverse effects
The extended pharmacokinetic profile allows therapeutic GLP-1 receptor activation throughout the day and night, providing continuous metabolic benefits rather than the transient effects of native GLP-1
Declaration of interest The authors report no conflicts of interest
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