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The key difference is that semaglutide users at the 2.4 mg dose report higher rates and longer duration of constipation compared to tirzepatide users, even at the highest 15 mg dose

All dosage information currently available is derived from clinical trial protocols rather than approved prescribing information, and should be interpreted within that context

Salt form uncertainty: some compounders used tirzepatide sodium or tirzepatide acetate forms not tested for safety or efficacy in humans

Combined effect is plausibly greater

SJS and TEN are rare and life-threatening, which are characterized by extensive bullae formation, epidermal necrolysis, and exfoliation