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Why they are paired: MK-677 (Ibutamoren) is an oral ghrelin mimetic with a 24-hour half-life

Both trials mainly reported CNS events, with no serious AEs

Additionally, depression raises markers for epithelial barrier dysfunction, such as zonulin, leading to increased intestinal permeability and circulating lipopolysaccharide (LPS) levels

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The study emphasizes that cerebrovascular benefits observed with semaglutide do not generalize to the entire GLP-1RA class