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1.1.3.2 The COMPASS complex The COMPASS (Complex of Proteins Associated with Set1) complex is a highly conserved and well-studied group of histone methyltransferases found in eukaryotic organisms, where it plays a crucial role in the regulation of gene expression through the methylation of histone H3 at lysine 4 (H3K4) (Eissenberg and Shilatifard, 2010