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While switching, youll want to track the progress towards achieving significant weight loss: body weight and waist circumference (to monitor fat loss and body composition) blood sugar / HbA1c / fasting insulin (for glycemic control) blood pressure and heart rate (some of these medications can raise heart-rate) side-effects: GI symptoms (nausea, vomiting), possible more intense responses with retatrutide your diet, hydration status, and workout/energy levels (as your body adjusts to the new medicine) Regular check-ins (every 4 weeks initially) help your provider catch anything needing adjustment
Sci Rep 11 , 22521 (2021)
The following stepwise schedule mirrors the inverse of the titration ladder: | Week | Taper Step | Notes | |---|---|---| | Week 1 to 2 | Reduce from 12 mg to 8 mg | Monitor weight and GI symptoms | | Week 3 to 4 | Remain at 8 mg | Confirm tolerability of step-down | | Week 5 to 6 | Reduce from 8 mg to 4 mg | Expect modest appetite increase | | Week 7 to 8 | Remain at 4 mg | Reinforce dietary structure | | Week 9 to 10 | Reduce from 4 mg to 2 mg | Begin transition plan | | Week 11 to 12 | Final 2 mg injection, then stop | Schedule 4-week follow-up | Patients stopping from an 8 mg maintenance dose begin the taper at that level and follow the same 4 mg and 2 mg steps over 8 weeks
Key Points Semaglutide (Ozempic, Wegovy) works by targeting one hormone (GLP-1), while tirzepatide (Mounjaro, Zepbound) targets two hormones (GLP-1 and GIP) for a dual-action effect
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