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Enzymatic cleavage and low permeability across epithelial layers reduce oral bioavailability
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ERK1/2 & VEGFR2 Mechanism Musculoskeletal Scoping Review (PMC, 2025) A 2025 scoping review confirmed BPC-157 activates VEGFR2 and drives nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilisation
While its primary action involves p53 release, the modulation of FOXO4-related pathways intersects with cellular stress-response systems
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