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Augmented mitochondrial autophagy facilitates cell survival initially, while excessive activation of mitochondrial autophagy results in cell death and tissue injury [33]
Nampoothiri S, Sauve F, Ternier G, Fernandois D, Coelho C, Imbernon M, Deligia E, Perbet R, Florent V, Baroncini M, Pasquier F, Trottein F, Maurage C-A, Mattot V, Giacobini P, Rasika S, Prevot V (2020) The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis
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(2016) 11:e0153380
From a clinical perspective, interventions aimed at increasing the blood glutathione pool do not necessarily need to be rapid, and thus the difference between achieving maximal absorption in minutes versus hours was not as important as the more general ability to simply absorb gluathione into the bloodstream
