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Palatin Technologies has two additional MC4R agonists, PL-7737 which is an oral small molecule, and PL-8905 which is a synthetic peptide, both in preclinical development for obesity indications, with the former specifically targeting obesity caused by LEPR deficiency 15
Azuri et al
In a Cleveland Clinic study of patients who stopped a semaglutide (Ozempic, Wegovy) or tirzepatide (Zepbound) product, nearly half cited out-of-pocket cost as the primary reason
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