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Of the approximately 90 metabolic enzyme networks available for such analysis, glycolysis/gluconeogenesis and the tricarboxylic acid (TCA) cycle were chosen, given both their relevance to normal myocardial metabolism, and their inclusion among the list of the most upregulated processes in the semaglutide-treated ischemic myocardial proteome

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For instance, GLP-1RAs can improve the levels of insulin, regulate the levels of sex hormone, improve the blood lipid profile, increase the levels of adiponectin, regulate autophagy, inhibit the production of liver glucose, reduce the liver fat content, as well as reduce the levels of plasma liver enzymes and liver steatosis

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