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Although the use of high volumes of lipid emulsion (especially 30%) in premature and low birth weight neonates has been associated with death from fat accumulation in the lungs, there are case reports in neonates, toddlers, and older children of successful reversal of drug overdose (bupivacaine and non-LAs) using standard recommended regimes of 20% lipid

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Zinc deficiency also allows increases in immune system messenger proteins cytokines that tend to promote inflammation