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Starting Dose and Titration Schedule Retatrutide phase 2 used a structured titration: Weeks 1 to 4: 2 mg subcutaneous once weekly Weeks 5 to 8: 4 mg once weekly Weeks 9 to 12: 8 mg once weekly Week 13 onward: 12 mg once weekly (maximum dose) Gastrointestinal adverse events drove dose reductions in 15.7% of participants receiving 12 mg in the phase 2 trial

Build time into the workflow Patients often appreciate it when providers take time to discuss financial concerns

Inflammopharmacology 7:114 Lovric-Bencic M, Sikiric P, Hanzevacki JS, Seiwerth S, Rogic D, Kusec V, Aralica G, Konjevoda P, Batelja L, Blagaic AB (2004) Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse

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In clinical studies, Glutathione is well-tolerated at typical doses