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40 Nevertheless, accumulating evidence indicates that CR is detrimental to skeletal metabolism, as evidenced by reductions in BMD and bone mineral content (BMC), diminished bone formation indices (e.g., bone formation rate, osteoblast number), and a concomitant increase in bone resorption
If your animal or cell model is concurrently exposed to high levels of systemic corticosteroids, the tissue repair mechanics may be entirely blunted, leading to unrepeatable or failed baseline data
N Engl J Med 2011;364:81828
Presented for research literature review only Banger KK et al
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