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So adjunctive therapies are supposed to be therapies that help insulin with glucose-lowering. The history of adjunctive therapies in type 1 diabetes began with metformin, an oral medication approved in the U.S

Biochem Soc Trans 2014

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The dependence of tyrosine hydroxylase on BH 4 necessitates the coupling to the action of dihydropteridine reductase (encoded by the QDPR gene: quinoid dihydropteridine reductase) as is the situation for tryptophan hydroxylase (see below) and phenylalanine hydroxylase

doi: 10.2337/db18-1123 22 YipRGBoylanMOKiefferTJWolfeMM