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Presented for research literature review only Cakir Y et al

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Chronic hypoxia for 7 or 14 d, but not 1 or 3 d, resulted in alpha-synuclein hyperphosphorylation at serine129 (-Syn p-S129) and protein aggregation, hippocampal neurodegeneration, and cognitive deficits, whereas the latter could be prevented by alpha-synuclein knockdown or an administered short peptide competing at -Syn S129

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Aside from maintaining the integrity of cell membranes throughout the body, -tocopherol protects the fats in low-density lipoproteins (LDLs) from oxidation