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The short answer is that they work through different mechanisms and stacking them often produces better results than either alone
This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)
Ramnanan, C
That said, its worth comparing costs, including any savings offers or pharmacy discounts especially if this is a medication youre considering long term
Vizuete A, Hansen F, Negri E et al (2018) Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis
