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Food & Function , 16 (11), 45484561

Vitamins and neuroprotection Neurotrophins, a phylogenetically conserved family of secretory proteins comprising BDNF, NGF, neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5), orchestrate multifaceted roles in neurodevelopment, synaptic plasticity, and neuronal survival across both the central and peripheral nervous systems [65]

Unlike native IGF-1, which is rapidly bound and regulated by IGFBPs in circulation, IGF-1 LR3 was engineered to remain active longer, making it a useful tool for researchers studying sustained IGF-1 receptor signaling rather than the brief signaling windows native IGF-1 typically produces

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