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Int J Cancer
[28] [29] Selective Pressure and Enzyme Evolution [edit] The atmospheric accumulation of highly reactive O 2 likely exercised a strong selective pressure against anaerobic organisms, and led to the adaptive evolution of oxygen utilization in metabolism (Boden et al
Still, they are also a result of mitochondrial dysfunction, which occurs when mitochondria lose the protection of GSH, free radicals attack the mitochondria, and cellular energy decreases.8 Autoimmune conditions like multiple sclerosis, Crohns disease, rheumatoid arthritis, diabetes, Lyme disease, heavy metal load, organotoxins, and more all have mitochondrial dysfunction, low levels of GSH, and profound fatigue
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