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Galasso M, Gambino S, Romanelli MG, et al

Observational real-world data in patients with T2D receiving oral semaglutide for 26 weeks demonstrated preservation of fat-free and skeletal muscle mass despite significant losses in fat mass and visceral adipose tissue, suggesting that the magnitude of lean tissue change may depend on concomitant lifestyle behaviors, such as physical activity and diet [16]

Theres only one problem

CNS side effects including sedation and restlessness (akathisia) occur even at short-term doses in some patients

LLY's FDA-approved weight loss drug is Zepbound, known generically as tirzepatide