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In vivo studies in rodent and non-human primate models have investigated body composition changes, white adipose tissue vascular dynamics, and the selectivity of the targeting domain for adipose-associated vasculature, with studies in obese rhesus macaques documenting that Adipotide administration induced targeted apoptosis within white adipose tissue vasculature and documented changes in body weight and insulin sensitivity parameters under controlled conditions [2], making Adipotide a reference compound in vascular-targeted peptidomimetic research across adipose tissue biology and ligand-directed apoptosis models

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