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Extra weight increases mechanical stress on the knee, and "visceral adipose tissue secretes adipocytokines and other soluble mediators that increase pain." Felson added that the trial's findings are similar to those from a 2023 study that examined the effects of GLP-1 receptor agonists on adults who had both type 2 diabetes and knee osteoarthritis
There are no other absolute contraindications definitively established for ALA
Gradual activity progression : If increasing physical activity following weight loss, do so gradually to allow joints and muscles time to adapt to new demands
Don't let enthusiasm push you up faster
Research comparing routes of administration is ongoing and findings are mixed, so the practical difference for any individual patient is a question for their prescribing provider
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