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In metabolic conditions such as diabetes, prolonged hyperglycemia can damage small nerve fibers through multiple pathways including oxidative stress, accumulation of advanced glycation end products, and microvascular insufficiency affecting nerve blood supply

For preemptive analgesia, 4 mg/kg of carprofen was given once just before surgery and continued every 24 hours for 3 days postoperatively [2]

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Abbreviations: DXA, dual-energy X-ray absorptiometry