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Direct injection of 1 nmol GLP-1, exendin-4, or liraglutide to the ARC significantly suppressed food intake and body weight, with the effects observed over the 24 hours following injection [71,79,80]
Retatrutide may offer an advantage here
GLP-1 receptor agonists have entered the cultural bloodstream as forcefully as any medication in recent memory with more than one in eight Americans now reporting having used one, and TikTok hosting over 384,500 posts tagged #Ozempic as of early 2025
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