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It works at the level of the mitochondria to improve: Insulin sensitivity Metabolic flexibility Glucose regulation Exercise adaptation Improving resting metabolic rate and ensuring enough sleep can further enhance the metabolic benefits of MOTS-c

8% (6/80) with control treatment (Newsome et al., 2021)

Mechanistically, testosterone still has a clear role in improving insulin sensitivity indirectly by promoting fat loss and muscle growth, both of which enhance the bodys ability to regulate blood sugar, says Lee

Prasad K

As a GHRH analog, its effect is gated by somatostatin (the inhibitory counter-signal), so it works within the body's natural regulatory feedback