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Gipr hypo-KO also abolishes the synergistic effect of a GIPR antagonist when combined with liraglutidean effect that is not mediated by nucleus tractus solitarius preproglucagon neurons

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GHRH/GHRP synergy characterisation: Foundational studies by Bowers, Thorner, and colleagues established that GHRH and synthetic GHRPs act through complementary pituitary signalling pathways cAMP and calcium respectively to produce synergistic GH release substantially exceeding that of either stimulus alone

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