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Sanyal, et al.s Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis from June, indicated significant efficacy of the GLP1-RA semaglutide in treating fatty liver disease, where it led to resolution of steatohepatitis without worsening of fibrosis in 63% of treated participants relative to 34% in the placebo group. The second trial demonstrated a dramatic effect of tirzepatide, a dual GIP and GLP-1RA, revealing a 10-fold reduction in the progression from prediabetes to type 2 diabetes, relative to placebo, in individuals with obesity who were treated with tirzepatide, Abel says
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