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So in patients for whom this matters, who may have heart disease, kidney disease, or obesity complications, then the benefits of GLP-1s do outweigh the potential risks, which are typically gastrointestinal side effects

It is therefore suggesting that the slight change of relaxation observed in the aorta without endothelium ex vivo might be due to some mechanism unrelated to the direct nitric oxide stimulation which needs further investigation

Appetite suppression: It slows gastric emptying (stomach emptying), reducing hunger and helping individuals manage calorie intake more effectively

This approach helps reduce side effects while still allowing for results