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A: GLP-1 agonists (like Ozempic or Wegovy) are FDA-approved hormonal drugs that mimic a gut hormone to regulate blood sugar, suppress appetite, and drive weight loss

(2019) 30:374384.e6

Very intense, prolonged exercise can actually cause temporary oxidative stress

In contrast to other GPxs, GPx4 is the only one that reduces the hydroperoxides of lipoproteins and complex lipids, such as cholesterol, cholesterol esters, and phospholipids [108], to protect mitochondrial ATP generation from oxidative damage [109]

The use of compounds that stimulate Sirtuin and AMPK modulators SIRT1/SIRT6 (e.g., resveratrol, NMN) has shown potential to restore mitochondrial biogenesis and attenuate OS in insulin-resistant tissues (Wang et al., 2023), although robust clinical trials are lacking