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This is the mechanistic basis for the higher GI discontinuation rate seen with CagriSema at maximum doses
B.KruhN
Bone 116 , 4246 (2018)
In cell-culture studies, gene-expression and protein-synthesis changes are described over hours to a few days
8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years
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