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I listened to a bunch of things, one of which was a Tegus call with a professor of cardiology that cited about one out of six patients have side effects that are so severe that they discontinue the drug
At 104 weeks (2 years), patients in this subgroup reached 30.3% average weight loss confirming that retatrutide doesn't plateau at the primary endpoint and continues to improve with extended treatment
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(2022) Tirzepatide once weekly for the treatment of obesity Juan P
Weight loss alone does not provide enough information to evaluate treatment success
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