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This step-up approach helps the body adjust and may reduce stomach-related side effects such as nausea

In the STEP clinical trial program evaluating Wegovy for weight management, participants achieved mean weight reductions of 12% to 15% of baseline body weight over 68 weeks, significantly exceeding results seen with lifestyle modification alone

The region-specific pattern of glutathione loss may also help guide future neuroimaging studies and more effective targeted therapies

Such reactions are generally mild and transient, resolving within a few days without specific intervention