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Phentermine is a CNS stimulant that primarily suppresses appetite through norepinephrine release
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Historically, the use of beta-blockers in individuals with ATTR-CM raised concern because of dependence on heart rate to maintain cardiac output, chronotropic incompetence from amyloid infiltration of the conduction system, and autonomic dysfunction
However , all uses remain strictly limited to laboratory environments
Timing Strategies : Distribute fluid intake throughout the day rather than consuming large volumes at once, which may exacerbate nausea or gastric discomfort
