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Abbreviations TDDS: Targeted drug delivery system Dox: Doxorubicin BBB: Blood-brain barrier CDDS: Controlled drug delivery system CNS: Central nerovous system NG: Nenogel NGs: Nenogels CNGs: Composite NGs HG: Hydrogel HGs: Hydrogels NP: Nanoparticle NPs: Nanoparticles MTX: Methotrexate References Su H, Wang Y, Liu S, Wang Y, Liu Q, Liu G, et al
The appetite decrease is of course part of the intended mechanism, but it can become excessive during aggressive titration, leading to inadequate caloric and protein intake

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This TME is defined by pervasive infiltrates of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and a dense mineralized extracellular matrix (ECM) barrier that collectively exclude or exhaust cytotoxic T cells