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doi: 10.1080/01485010390129269, 226
6 Although metformin is usually an effective treatment for regulating glucose levels, many patients with T2D have an elevated risk of cardiac events that does not improve in response to metformin
Finally, participants were filtered on relatedness such that no two people shared more than 700 cM identity by descent 37 , which corresponds approximately to the minimal expected sharing between first cousins in an outbred population, resulting in a final GWAS sample size of 15,237
Because physiological feedback loops involving somatostatin and IGF-1 remain intact, the risk of GH excess is substantially lower making it the appropriate entry point for patients new to peptide therapy and those who prefer a conservative, physiologically aligned approach
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