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This multistep procedure performs the preliminary hydrogen atoms addition employing the pdb2pqr 46 and PROPKA3 47 software combination through the systemPrepare HTMD implementation 48 , considering a simulated pH of 7.4

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Adapalene and Other Topical Medications Applying other topical medications such as corticosteroids, antifungals, or moisturizers with strong active ingredients may interfere with adapalenes effectiveness or increase irritation