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In a large, rigorous review of over 50 studies involving more than one million patients, metformin use in patients with type 2 diabetes was associated with a 35% reduction in risk of death from cancer, and a 27% reduction in risk of any cancer (Franciosi 2013)
Small number of research groups : A limited number of research groups have conducted most studies, which may affect the generalizability of the results
Indication : It is used for infertility (after other treatments), prepubertal cryptorchidism, and hypogonadotropic hypogonadism
doi: 10.1016/j.jmii.2014.04.014 546 ArshadFMehmoodRHussainSKhanMAKhanM
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