In an online survey of 153 adults with obesity, most of whom were white and women, those who took semaglutide or tirzepatide reported drinking significantly less than peers not on the medications
Disruption in iron homeostasis, including increased transferrin receptor expression and ferritin degradation via NCOA4-mediated ferritinophagy, contributes to ferroptotic susceptibility (Kuang et al., 2020)
As this was happening, career FDA scientists quietly argued in posts shared on the FDA website that there had not yet been enough clinical human trials to confirm that the peptides in question are both safe and effective for pharmacies to compound and distribute
Sciannameo V, Berchialla P, Orsi E, et al
Patients with preserved beta-cell function and insulin secretion capacity tend to respond better to incretin-based therapies