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By slowing down digestion, the medication ensures that meals stick with you longer, reducing the need for constant snacking

Beyond gastrointestinal effects, the following safety signals and class-relevant cautions warrant attention: Heart rate elevation: Retatrutide's glucagon receptor agonism has been associated with modest increases in resting heart rate in Phase 2 data

Most side effects are mild and resolve on their own (injection-site reactions, mild headache, water retention)

In comparison, the patients lost 17.5% of their body weight on average at 24 weeks and 24.2% of weight after 48 weeks in phase 2 clinical trials with retatrutide

Studies indicate that patients should aim for 1,500 calories daily for women and 2,000 calories daily for men to lose approximately one pound per week